7CRR

Native NSD3 bound to 187-bp nucleosome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (M, E)	Histone H3	polymer	135	15223.8	2	UniProt (Q92133) Pfam (PF00125)	Xenopus laevis (African clawed frog)
2	B, F (B, F)	Histone H4	polymer	102	11263.2	2	UniProt (P62799) Pfam (PF15511)	Xenopus laevis (African clawed frog)
3	C, G (C, G)	Histone H2A	polymer	129	13978.2	2	UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P06897)	Xenopus laevis (African clawed frog)
4	D, H (D, H)	Histone H2B	polymer	122	13524.8	2	UniProt (Q6AZK7) Pfam (PF00125) UniProt (by SIFTS) (P02281)	Xenopus tropicalis (Western clawed frog)
5	I (A)	DNA (168-MER)	polymer	187	57488.6	1		synthetic construct
6	J (K)	DNA(168-MER)	polymer	187	57982.9	1		synthetic construct
7	K (I)	Histone-lysine N-methyltransferase NSD3	polymer	758	85484.3	1	UniProt (Q9BZ95) Pfam (PF17907) Pfam (PF00856) Pfam (PF17982) Pfam (PF23011) Pfam (PF22908) Pfam (PF23004) Pfam (PF00855)	Homo sapiens (Human)	Nuclear SET domain-containing protein 3,Protein whistle,WHSC1-like 1 isoform 9 with methyltransferase activity to lysine,Wolf-Hirschhorn syndrome candidate 1-like protein 1,WHSC1-like protein 1
8	L (I)	S-ADENOSYLMETHIONINE	non-polymer		398.4	1	Chemie (SAM)
9	M, N, O (I)	ZINC ION	non-polymer		65.4	3	Chemie (ZN)

Sequence modifications

M, E: 1 - 135 (UniProt: Q92133)

PDB	External Database	Details
Nle 36	Lys 37	engineered mutation
Nle 90	Met 91	engineered mutation
Nle 120	Met 121	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	11
	Total formula weight	308935.8
Non-Polymers*	Number of molecules	4
	Total formula weight	594.7
All*	Total formula weight	309530.5

*Water molecules are not included.