7CRO
NSD2 bearing E1099K/T1150A dual mutation in complex with 187-bp NCP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | M, E | Histone H3 | polymer | 135 | 15223.8 | 2 | UniProt (Q92133) Pfam (PF00125) In PDB | Xenopus laevis (African clawed frog) | |
2 | B, F | Histone H4 | polymer | 102 | 11263.2 | 2 | UniProt (P62799) Pfam (PF15511) In PDB | Xenopus laevis (African clawed frog) | |
3 | C, G | Histone H2A | polymer | 129 | 13978.2 | 2 | UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P06897) In PDB | Xenopus laevis (African clawed frog) | |
4 | D, H | Histone H2B | polymer | 122 | 13524.8 | 2 | UniProt (Q6AZK7) Pfam (PF00125) UniProt (by SIFTS) (P02281) In PDB | Xenopus tropicalis (Western clawed frog) | |
5 | A | DNA (168-MER) | polymer | 187 | 57488.6 | 1 | Xenopus laevis | ||
6 | K | DNA (168-MER) | polymer | 187 | 57982.9 | 1 | Xenopus laevis | ||
7 | I | Histone-lysine N-methyltransferase NSD2 | polymer | 705 | 79688.8 | 1 | UniProt (O96028) Pfam (PF00855) Pfam (PF17907) Pfam (PF00856) Pfam (PF23011) Pfam (PF17982) Pfam (PF22908) Pfam (PF23004) Pfam (PF00628) In PDB | Homo sapiens (Human) | Multiple myeloma SET domain-containing protein,MMSET,Nuclear SET domain-containing protein 2,Protein trithorax-5,Wolf-Hirschhorn syndrome candidate 1 protein |
8 | I | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
9 | I | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) |
Sequence modifications
M, E: 1 - 135 (UniProt: Q92133)
I: 661 - 1365 (UniProt: O96028)
PDB | External Database | Details |
---|---|---|
Nle 36 | Lys 37 | engineered mutation |
Nle 90 | Met 91 | engineered mutation |
Nle 120 | Met 121 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Lys 1099 | Glu 1099 | engineered mutation |
Ala 1150 | Thr 1150 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 11 |
Total formula weight | 303140.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 594.7 | |
All* | Total formula weight | 303735.0 |