7COZ
Crystal Structure of double mutant Y115E Y117E human Secretory Glutaminyl Cyclase in complex with LSB-41
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Glutaminyl-peptide cyclotransferase | polymer | 327 | 37331.1 | 3 | UniProt (Q16769) Pfam (PF04389) | Homo sapiens (Human) | Glutaminyl cyclase,sQC,Glutaminyl-tRNA cyclotransferase,Glutamyl cyclase,EC |
| 2 | D, M, X (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | E, N, Y (A, B, C) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F, O, Z (A, B, C) | 1-[3-(2-methyl-4-thiophen-2-yl-1,3-thiazol-5-yl)propanoyl]piperidine-4-carboxamide | non-polymer | 363.5 | 3 | Chemie (Q39) | |||
| 5 | AA, BA, CA, DA, EA... (C, A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 21 | Chemie (EDO) | |||
| 6 | HA, IA, JA (A, B, C) | water | water | 18.0 | 776 | Chemie (HOH) |
Sequence modifications
A, B, C: 35 - 361 (UniProt: Q16769)
| PDB | External Database | Details |
|---|---|---|
| Glu 115 | Tyr 115 | engineered mutation |
| Glu 117 | Tyr 117 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 111993.4 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 2878.3 | |
| All* | Total formula weight | 114871.7 |
