7CO1

Crystal structure of SMAD2 in complex with wild-type CBP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E	Mothers against decapentaplegic homolog 2	polymer	208	23481.6	3	UniProt (Q15796) Pfam (PF03166) In PDB	Homo sapiens (Human)	Mothers against DPP homolog 2,JV18-1,Mad-related protein 2,hMAD-2,SMAD family member 2,hSMAD2
2	B, D, F	CREB-binding protein	polymer	28	3137.3	3	UniProt (Q92793) In PDB	Homo sapiens (Human)	Histone lysine acetyltransferase CREBBP,Protein-lysine acetyltransferase CREBBP

Sequence modifications

A, C, E: 262 - 467 (UniProt: Q15796)

PDB	External Database	Details
Gly 260	-	expression tag
Pro 261	-	expression tag
Glu 465	Ser 465	engineered mutation
Glu 467	Ser 467	engineered mutation

B, D, F: 1951 - 1973 (UniProt: Q92793)

PDB	External Database	Details
Gly 1950	-	expression tag
Ser 1974	-	expression tag
Asp 1975	-	expression tag
Glu 1976	-	expression tag
Asp 1977	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	79856.7
All*	Total formula weight	79856.7

*Water molecules are not included.