7CND
NCI-1 in complex with CRM1-Ran-RanBP1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GTP-binding nuclear protein Ran | polymer | 216 | 24399.1 | 1 | UniProt (P62826) Pfam (PF00071) | Homo sapiens (Human) | Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein |
| 2 | B (B) | YRB1 isoform 1 | polymer | 140 | 16320.7 | 1 | UniProt (A0A6A5PZB5) Pfam (PF00638) UniProt (by SIFTS) (P41920) | Saccharomyces cerevisiae (Baker's yeast) | |
| 3 | C (C) | CRM1 isoform 1 | polymer | 1003 | 115222.4 | 1 | UniProt (A0A6A5PZI8) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) UniProt (by SIFTS) (P30822) | Saccharomyces cerevisiae (Baker's yeast) | |
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 6 | F, G, K, L, N... (A, C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 6 | Chemie (DMS) | |||
| 7 | H, I, O, P, Q... (A, B, C) | CHLORIDE ION | non-polymer | 35.5 | 9 | Chemie (CL) | |||
| 8 | J (C) | ~{N}-[(~{E})-3-[3,5-bis(trifluoromethyl)phenyl]sulfinylprop-2-enyl]-3-methyl-butan-1-amine | non-polymer | 387.4 | 1 | Chemie (G6U) | |||
| 9 | M (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 10 | R (C) | 3[N-MORPHOLINO]PROPANE SULFONIC ACID | non-polymer | 209.3 | 1 | Chemie (MPO) | |||
| 11 | X, Y, Z (A, B, C) | water | water | 18.0 | 773 | Chemie (HOH) |
Sequence modifications
A: 1 - 216 (UniProt: P62826)
C: 1 - 1058 (UniProt: A0A6A5PZI8)
| PDB | External Database | Details |
|---|---|---|
| Leu 69 | Gln 69 | engineered mutation |
| Ala 182 | Leu 182 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Glu 27 | Ser 27 | engineered mutation |
| Glu 49 | Gln 49 | engineered mutation |
| Val 51 | Ala 51 | conflict |
| - | Val 377 | deletion |
| - | Gln 378 | deletion |
| - | Arg 379 | deletion |
| - | Leu 380 | deletion |
| - | Pro 381 | deletion |
| - | Ala 382 | deletion |
| - | Thr 383 | deletion |
| - | Glu 384 | deletion |
| - | Met 385 | deletion |
| - | Ser 386 | deletion |
| - | Pro 387 | deletion |
| - | Leu 388 | deletion |
| - | Ile 389 | deletion |
| - | Gln 390 | deletion |
| - | Leu 391 | deletion |
| - | Ser 392 | deletion |
| - | Val 393 | deletion |
| - | Gly 394 | deletion |
| - | Ser 395 | deletion |
| - | Gln 396 | deletion |
| - | Ala 397 | deletion |
| - | Ile 398 | deletion |
| - | Ser 399 | deletion |
| - | Thr 400 | deletion |
| - | Gly 401 | deletion |
| - | Ser 402 | deletion |
| - | Gly 403 | deletion |
| - | Ala 404 | deletion |
| - | Leu 405 | deletion |
| - | Asn 406 | deletion |
| - | Pro 407 | deletion |
| - | Glu 408 | deletion |
| - | Tyr 409 | deletion |
| - | Met 410 | deletion |
| - | Lys 411 | deletion |
| - | Arg 412 | deletion |
| - | Phe 413 | deletion |
| - | Val 441 | deletion |
| - | Leu 442 | deletion |
| - | Val 443 | deletion |
| - | Val 444 | deletion |
| - | Glu 445 | deletion |
| - | Asn 446 | deletion |
| - | Asp 447 | deletion |
| - | Glu 448 | deletion |
| - | Gly 449 | deletion |
| - | Glu 450 | deletion |
| - | Ile 451 | deletion |
| - | Val 452 | deletion |
| - | Arg 453 | deletion |
| - | Glu 454 | deletion |
| - | Phe 455 | deletion |
| - | Val 456 | deletion |
| - | Lys 457 | deletion |
| - | Glu 458 | deletion |
| - | Ser 459 | deletion |
| - | Asp 460 | deletion |
| - | Thr 461 | deletion |
| Gly 537 | Asp 537 | engineered mutation |
| Glu 540 | Val 540 | engineered mutation |
| Gln 541 | Lys 541 | engineered mutation |
| Arg 553 | Ser 553 | engineered mutation |
| Glu 561 | Gln 561 | engineered mutation |
| Thr 741 | Ala 741 | engineered mutation |
| Cys 1022 | Tyr 1022 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 155942.2 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2024.1 | |
| All* | Total formula weight | 157966.3 |
