7CIO
Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 3-kinase regulatory subunit alpha | polymer | 109 | 12178.5 | 1 | UniProt (P27986) Pfam (PF00017) | Homo sapiens (Human) | PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha |
| 2 | B (B) | Cytotoxic T-lymphocyte protein 4 | polymer | 8 | 971.1 | 1 | UniProt (P16410) | Homo sapiens | Cytotoxic T-lymphocyte-associated antigen 4,CTLA-4 |
| 3 | C, D (A, B) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A: 614 - 720 (UniProt: P27986)
| PDB | External Database | Details |
|---|---|---|
| Gly 612 | - | expression tag |
| Ser 613 | - | expression tag |
| Ser 656 | Cys 656 | engineered mutation |
| Val 659 | Cys 659 | engineered mutation |
| Leu 670 | Cys 670 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 13149.6 | |
| All* | Total formula weight | 13149.6 |
