7CEB

Crystal structure of alpha6beta1 integrin headpiece

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Integrin alpha-6	polymer	627	69776.0	1	UniProt (P23229) Pfam (PF01839) Pfam (PF08441)	Homo sapiens (Human)	CD49 antigen-like family member F,VLA-6
2	B (B)	Integrin beta-1	polymer	454	50510.9	1	UniProt (P05556) Pfam (PF17205) Pfam (PF00362)	Homo sapiens (Human)	Fibronectin receptor subunit beta,Glycoprotein IIa,GPIIA,VLA-4 subunit beta
3	C (C)	TS2/16 VH(S112C)-SARAH	polymer	172	19464.0	1	Pfam (PF11629) UniProt (by SIFTS) (Q13043)	Mus musculus (Mouse)
4	D (D)	TS2/16 VL-SARAH(S37C)	polymer	164	18270.7	1	Pfam (PF11629) UniProt (by SIFTS) (Q13043)	Mus musculus (Mouse)
5	E, F, G, J (A, B)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
6	H, I, L, M, N... (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
7	K (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
8	P, Q (A, B)	water	water		18.0	3	Chemie (HOH)

Sequence modifications

A: 1 - 618 (UniProt: P23229)

PDB	External Database	Details
Gly 619	-	expression tag
Ser 620	-	expression tag
Leu 621	-	expression tag
Glu 622	-	expression tag
Asn 623	-	expression tag
Leu 624	-	expression tag
Tyr 625	-	expression tag
Phe 626	-	expression tag
Gln 627	-	expression tag

B: 1 - 445 (UniProt: P05556)

PDB	External Database	Details
Gly 446	-	expression tag
Gly 447	-	expression tag
Leu 448	-	expression tag
Glu 449	-	expression tag
Asn 450	-	expression tag
Leu 451	-	expression tag
Tyr 452	-	expression tag
Phe 453	-	expression tag
Gln 454	-	expression tag

C: 0 - 113 (PDB: 7CEB)
C: 114 - 164 (PDB: 7CEB)
D: -3 - 108 (PDB: 7CEB)
D: 109 - 159 (PDB: 7CEB)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	158021.7
Non-Polymers*	Number of molecules	11
	Total formula weight	1511.9
All*	Total formula weight	159533.6

*Water molecules are not included.