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7CBX

Crystal structure of MAP2K7 complexed with a covalent inhibitor 12

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ADual specificity mitogen-activated protein kinase kinase 7polymer32336851.61UniProt (O14733)
Pfam (PF00069)
In PDB
Homo sapiens (Human)MAPKK 7,JNK-activating kinase 2,MAPK/ERK kinase 7,MEK 7,Stress-activated protein kinase kinase 4,SAPKK4,c-Jun N-terminal kinase kinase 2,JNKK 2
2A3-(1H-indazol-3-yl)-5-(prop-2-enoylamino)-N-prop-2-ynyl-benzamidenon-polymer344.41Chemie (FU6)
3AGLYCEROLnon-polymer92.11Chemie (GOL)
4waterwater18.0104Chemie (HOH)
Sequence modifications
A: 119 - 435 (UniProt: O14733)
PDBExternal DatabaseDetails
Ser 218Cys 202engineered mutation
His 436-expression tag
His 437-expression tag
His 438-expression tag
His 439-expression tag
His 440-expression tag
His 441-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight36851.6
Non-Polymers*Number of molecules2
Total formula weight436.5
All*Total formula weight37288.1
*Water molecules are not included.

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PDB entries from 2024-06-12

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