7C7S

Cryo-EM structure of the CGP54626-bound human GABA(B) receptor in inactive state.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Gamma-aminobutyric acid type B receptor subunit 1	polymer	937	105976.3	1	UniProt (Q9UBS5) Pfam (PF00084) Pfam (PF01094) Pfam (PF00003) In PDB	Homo sapiens (Human)	Gb1
2	B	Gamma-aminobutyric acid type B receptor subunit 2	polymer	808	91359.4	1	UniProt (O75899) Pfam (PF01094) Pfam (PF00003) Pfam (PF18455) In PDB	Homo sapiens (Human)	Gb2,G-protein coupled receptor 51,HG20
3	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
4	A	(R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid	non-polymer		408.3	1	Chemie (2BV)

Sequence modifications

A: 15 - 919 (UniProt: Q9UBS5)

PDB	External Database	Details
Met -1	-	expression tag
Lys 0	-	expression tag
Thr 1	-	expression tag
Ile 2	-	expression tag
Ile 3	-	expression tag
Ala 4	-	expression tag
Leu 5	-	expression tag
Ser 6	-	expression tag
Tyr 7	-	expression tag
Ile 8	-	expression tag
Phe 9	-	expression tag
Cys 10	-	expression tag
Leu 11	-	expression tag
Val 12	-	expression tag
Phe 13	-	expression tag
Ala 14	-	expression tag
Leu 920	-	expression tag
Glu 921	-	expression tag
Val 922	-	expression tag
Leu 923	-	expression tag
Phe 924	-	expression tag
Gln 925	-	expression tag
Gly 926	-	expression tag
Pro 927	-	expression tag
His 928	-	expression tag
His 929	-	expression tag
His 930	-	expression tag
His 931	-	expression tag
His 932	-	expression tag
His 933	-	expression tag
His 934	-	expression tag
His 935	-	expression tag

B: 41 - 819 (UniProt: O75899)

PDB	External Database	Details
Met 12	-	expression tag
Lys 13	-	expression tag
Thr 14	-	expression tag
Ile 15	-	expression tag
Ile 16	-	expression tag
Ala 17	-	expression tag
Leu 18	-	expression tag
Ser 19	-	expression tag
Tyr 20	-	expression tag
Ile 21	-	expression tag
Phe 22	-	expression tag
Cys 23	-	expression tag
Leu 24	-	expression tag
Val 25	-	expression tag
Phe 26	-	expression tag
Ala 27	-	expression tag
Asp 28	-	expression tag
Tyr 29	-	expression tag
Lys 30	-	expression tag
Asp 31	-	expression tag
Asp 32	-	expression tag
Asp 33	-	expression tag
Asp 34	-	expression tag
Lys 35	-	expression tag
Gly 36	-	expression tag
Ser 37	-	expression tag
Gly 38	-	expression tag
Gly 39	-	expression tag
Ser 40	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	197335.7
Non-Polymers*	Number of molecules	9
	Total formula weight	2178.0
All*	Total formula weight	199513.7

*Water molecules are not included.