7C3N
Crystal structure of JAK3 in complex with Delgocitinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK3 | polymer | 315 | 35846.7 | 1 | UniProt (P52333) Pfam (PF07714) | Homo sapiens (Human) | Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK |
| 2 | B (A) | 3-[(3S,4R)-3-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile | non-polymer | 310.4 | 1 | Chemie (FHX) | |||
| 3 | C (A) | water | water | 18.0 | 267 | Chemie (HOH) |
Sequence modifications
A: 812 - 1124 (UniProt: P52333)
| PDB | External Database | Details |
|---|---|---|
| Gly 810 | - | expression tag |
| Ser 811 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35846.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 310.4 | |
| All* | Total formula weight | 36157.0 |
