7C2V
Crystal Structure of IRAK4 kinase in complex with the inhibitor CA-4948
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Interleukin-1 receptor-associated kinase 4 | polymer | 300 | 33857.1 | 4 | UniProt (Q9NWZ3) Pfam (PF07714) In PDB | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
| 2 | A, B, C, D | 2-(2-methylpyridin-4-yl)-N-[2-morpholin-4-yl-5-[(3R)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide | non-polymer | 491.5 | 4 | Chemie (FJ0) | |||
| 3 | water | water | 18.0 | 402 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 162 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Ser 161 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 135428.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1966.0 | |
| All* | Total formula weight | 137394.3 |
