7BYL
Cryo-EM structure of human KCNQ4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, C, E, G) | Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4 | polymer | 979 | 109327.8 | 4 | UniProt (P42212) UniProt (P56696) Pfam (PF00520) Pfam (PF03520) | Aequorea victoria (Jellyfish) | KQT-like 4,Potassium channel subunit alpha KvLQT4,Voltage-gated potassium channel subunit Kv7.4 |
| 2 | E, F, G, H (B, D, F, H) | Calmodulin-3 | polymer | 149 | 16852.5 | 4 | UniProt (P0DP25) Pfam (PF13499) | Homo sapiens (Human) | |
| 3 | I, N, O, P (A, C, E, G) | [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | non-polymer | 1047.1 | 4 | Chemie (PT5) PubChem (21584053) PubChem (46891800) PubChem (24742075) PubChem (25021172) PubChem (53480261) PubChem (49867532) PubChem (53731018) PubChem (74343116) PubChem (644093) PubChem (88368868) PubChem (101127471) PubChem (5497157) PubChem (101103400) PubChem (137349554) PubChem (146672970) PubChem (162802760) PubChem (177693253) PubChem (137349667) PubChem (155387720) | |||
| 4 | J, K, L, M (A) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) PubChem (813) | |||
| 5 | Q, R, S, T (A, C, E, G) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A, C, E, G: -253 - -17 (UniProt: P42212)
A, C, E, G: 1 - 695 (UniProt: P56696)
| PDB | External Database | Details |
|---|---|---|
| Met -283 | - | expression tag |
| His -282 | - | expression tag |
| His -281 | - | expression tag |
| His -280 | - | expression tag |
| His -279 | - | expression tag |
| His -278 | - | expression tag |
| His -277 | - | expression tag |
| His -276 | - | expression tag |
| His -275 | - | expression tag |
| Ala -274 | - | expression tag |
| Ala -273 | - | expression tag |
| Asp -272 | - | expression tag |
| Tyr -271 | - | expression tag |
| Lys -270 | - | expression tag |
| Asp -269 | - | expression tag |
| His -268 | - | expression tag |
| Asp -267 | - | expression tag |
| Ile -266 | - | expression tag |
| Asp -265 | - | expression tag |
| Tyr -264 | - | expression tag |
| Lys -263 | - | expression tag |
| Asp -262 | - | expression tag |
| Asp -261 | - | expression tag |
| Asp -260 | - | expression tag |
| Asp -259 | - | expression tag |
| Lys -258 | - | expression tag |
| Ser -257 | - | expression tag |
| Ala -256 | - | expression tag |
| Met -255 | - | expression tag |
| Val -254 | - | expression tag |
| Leu -191 | Phe 64 | engineered mutation |
| Thr -190 | Ser 65 | engineered mutation |
| Thr -148 | Lys 107 | engineered mutation |
| Lys -49 | Ala 206 | engineered mutation |
| Leu -24 | His 231 | engineered mutation |
| Ser -16 | - | linker |
| Gly -15 | - | linker |
| Leu -14 | - | linker |
| Arg -13 | - | linker |
| Ser -12 | - | linker |
| Gly -11 | - | linker |
| Leu -10 | - | linker |
| Glu -9 | - | linker |
| Val -8 | - | linker |
| Leu -7 | - | linker |
| Phe -6 | - | linker |
| Gln -5 | - | linker |
| Gly -4 | - | linker |
| Pro -3 | - | linker |
| Gly -2 | - | linker |
| Gly -1 | - | linker |
| Arg 0 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 504721.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 4344.7 | |
| All* | Total formula weight | 509066.3 |
