7BYD
Crystal structure of SN45 TCR in complex with lipopeptide-bound Mamu-B*05104
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F (A, F) | B protein | polymer | 276 | 31919.2 | 2 | UniProt (B2ZHY7) Pfam (PF00129) Pfam (PF07654) | Macaca mulatta (Rhesus macaque) | MHC class I antigen, MHC-class I protein |
| 2 | B, G (B, G) | Beta-2-microglobulin | polymer | 100 | 11731.2 | 2 | UniProt (Q6V7J5) Pfam (PF07654) | Macaca mulatta (Rhesus macaque) | |
| 3 | C, H (C, H) | GLY-GLY-ALA-ILE | polymer | 4 | 316.4 | 2 | Simian immunodeficiency virus | ||
| 4 | D, I (D, I) | SN45 T cell receptor alpha chain | polymer | 198 | 21809.4 | 2 | Macaca mulatta | ||
| 5 | E, J (E, J) | SN45 T cell receptor beta chain | polymer | 245 | 28086.6 | 2 | Macaca mulatta | ||
| 6 | BA, EA, FA, GA, HA... (G, I, A, J, B...) | IODIDE ION | non-polymer | 126.9 | 19 | Chemie (IOD) | |||
| 7 | AA, CA, IA, O (F, G, I, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 8 | R (B) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 9 | S (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 10 | DA, T (H, C) | MYRISTIC ACID | non-polymer | 228.4 | 2 | Chemie (MYR) | |||
| 11 | JA (I) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 12 | MA, NA, OA, PA, QA... (A, B, D, F, G...) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A, F: 1 - 276 (UniProt: B2ZHY7)
| PDB | External Database | Details |
|---|---|---|
| Glu 128 | Arg 149 | engineered mutation |
| Glu 177 | Lys 198 | engineered mutation |
| Glu 223 | Asp 244 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 187725.3 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 3301.4 | |
| All* | Total formula weight | 191026.7 |
