7BYD

Crystal structure of SN45 TCR in complex with lipopeptide-bound Mamu-B*05104

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F	B protein	polymer	276	31919.2	2	UniProt (B2ZHY7) Pfam (PF00129) Pfam (PF07654) In PDB	Macaca mulatta (Rhesus macaque)	MHC class I antigen, MHC-class I protein
2	B, G	Beta-2-microglobulin	polymer	100	11731.2	2	UniProt (Q6V7J5) Pfam (PF07654) In PDB	Macaca mulatta (Rhesus macaque)
3	C, H	GLY-GLY-ALA-ILE	polymer	4	316.4	2		Simian immunodeficiency virus
4	D, I	SN45 T cell receptor alpha chain	polymer	198	21809.4	2		Macaca mulatta
5	E, J	SN45 T cell receptor beta chain	polymer	245	28086.6	2		Macaca mulatta
6	G, I, A, J, B...	IODIDE ION	non-polymer		126.9	19	Chemie (IOD)
7	F, G, I, A	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
8	B	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		122.1	1	Chemie (TRS)
9	B	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
10	H, C	MYRISTIC ACID	non-polymer		228.4	2	Chemie (MYR)
11	I	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
12		water	water		18.0	50	Chemie (HOH)

Sequence modifications

A, F: 1 - 276 (UniProt: B2ZHY7)

PDB	External Database	Details
Glu 128	Arg 149	engineered mutation
Glu 177	Lys 198	engineered mutation
Glu 223	Asp 244	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	187725.3
Non-Polymers*	Number of molecules	28
	Total formula weight	3301.4
All*	Total formula weight	191026.7

*Water molecules are not included.