7BWD
Structure of Dot1L-H2BK34ub Nucleosome Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (K) | Histone-lysine N-methyltransferase, H3 lysine-79 specific | polymer | 416 | 47506.2 | 1 | UniProt (Q8TEK3) Pfam (PF08123) | Homo sapiens (Human) | DOT1-like protein,Histone H3-K79 methyltransferase,H3-K79-HMTase,Lysine N-methyltransferase 4 |
| 2 | B, I (F, B) | Histone H4 | polymer | 102 | 11263.2 | 2 | UniProt (P62805) Pfam (PF15511) | Homo sapiens (Human) | |
| 3 | C, H (G, C) | Histone H2A type 1-B/E | polymer | 129 | 14034.4 | 2 | UniProt (P04908) Pfam (PF00125) Pfam (PF16211) | Homo sapiens (Human) | Histone H2A.2,Histone H2A/a,Histone H2A/m |
| 4 | D, G (H, D) | Histone H2B type 1-K | polymer | 125 | 13790.0 | 2 | UniProt (O60814) Pfam (PF00125) | Homo sapiens (Human) | H2B K,HIRA-interacting protein 1 |
| 5 | E, F (E, A) | Histone H3.1 | polymer | 135 | 15306.0 | 2 | UniProt (P68431) Pfam (PF00125) | Homo sapiens (Human) | Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l |
| 6 | J (I) | DNA (146-MER) | polymer | 146 | 44825.6 | 1 | Homo sapiens | ||
| 7 | K (J) | DNA (146-MER) | polymer | 146 | 45305.9 | 1 | Homo sapiens | ||
| 8 | L, M (L, M) | Ubiquitin | polymer | 76 | 8622.9 | 2 | UniProt (P62979) Pfam (PF00240) | Homo sapiens (Human) | |
| 9 | N (K) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) |
Sequence modifications
L, M: 1 - 76 (UniProt: P62979)
| PDB | External Database | Details |
|---|---|---|
| Cys 76 | Gly 76 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 13 |
| Total formula weight | 263670.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 384.4 | |
| All* | Total formula weight | 264055.0 |
