7BW8

Cryo-EM Structure for the Insulin Binding Region in the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, C)	Insulin receptor	polymer	1355	154114.5	2	UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) Pfam (PF07714)	Homo sapiens (Human)	IR
2	C (D)	Insulin fusion	polymer	74	8380.5	1	UniProt (P01308) UniProt (A6XGL2) Pfam (PF00049)	Homo sapiens (Human)

Sequence modifications

D: 1 - 31 (UniProt: P01308)
D: 32 - 55 (UniProt: A6XGL2)
D: 56 - 76 (UniProt: P01308)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	316609.6
All*	Total formula weight	316609.6

*Water molecules are not included.