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7BU7

Structure of human beta1 adrenergic receptor bound to BI-167107 and nanobody 6B9

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Endolysin,Endolysin,Beta-1 adrenergic receptor chimerapolymer51657625.11UniProt (D9IEF7)
Pfam (PF00959)
Pfam (PF00001)
UniProt (by SIFTS) (P08588)
Enterobacteria phage T4Lysis protein,Lysozyme,Muramidase
2B
(B)
camelid antibody fragmentpolymer12814020.51Camelidae mixed library
3C, D
(C, D)
alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranosebranched342.32In PDB
BIRD (PRD_900001)
GlyTouCan (G07411ON)
alpha-maltose
4E, F, G, H, I...
(A)
SULFATE IONnon-polymer96.16Chemie (SO4)
5K
(A)
CHOLESTEROLnon-polymer386.71Chemie (CLR)
6L
(A)
(2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoatenon-polymer300.41Chemie (1WV)
7M
(A)
SODIUM IONnon-polymer23.01Chemie (NA)
8N
(A)
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACIDnon-polymer238.31Chemie (EPE)
9O
(A)
8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-onenon-polymer370.41Chemie (P0G)
10P
(A)
HEXAETHYLENE GLYCOLnon-polymer282.31Chemie (P6G)
11Q
(A)
waterwater18.025Chemie (HOH)
Sequence modifications
A: 892 - 1051 (UniProt: D9IEF7)
PDBExternal DatabaseDetails
Asp 884-expression tag
Tyr 885-expression tag
Lys 886-expression tag
Asp 887-expression tag
Asp 888-expression tag
Asp 889-expression tag
Asp 890-expression tag
Ala 891-expression tag
Thr 944Cys 54engineered mutation
Ala 987Cys 97engineered mutation
Ala 1052-linker
Ala 1053-linker
A: 1054 - 1399 (PDB: 7BU7)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight71645.6
BranchedNumber of molecules2
Total formula weight684.6
Non-Polymers*Number of molecules12
Total formula weight2177.5
All*Total formula weight74507.8
*Water molecules are not included.

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PDB entries from 2024-11-20

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