7BSU
Cryo-EM structure of a human ATP11C-CDC50A flippase in PtdSer-bound E2BeF state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ATP11C | polymer | 1084 | 124468.6 | 1 | Pfam (PF16209) Pfam (PF00122) Pfam (PF13246) Pfam (PF16212) UniProt (by SIFTS) (Q8NB49) | Homo sapiens | |
| 2 | B (C) | Cell cycle control protein 50A | polymer | 361 | 40900.8 | 1 | UniProt (Q9NV96) Pfam (PF03381) | Homo sapiens (Human) | P4-ATPase flippase complex beta subunit TMEM30A,Transmembrane protein 30A |
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine | non-polymer | 792.1 | 1 | Chemie (P5S) | |||
| 5 | E, F, H, I (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 6 | G (C) | 1-deoxy-alpha-D-mannopyranose | non-polymer | 164.2 | 1 | Chemie (AH2) |
Sequence modifications
C: 1 - 361 (UniProt: Q9NV96)
| PDB | External Database | Details |
|---|---|---|
| Met 175 | Ala 175 | engineered mutation |
| Gln 190 | Asn 190 | engineered mutation |
| Trp 292 | Ser 292 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 165369.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1865.4 | |
| All* | Total formula weight | 167234.8 |
