7BKQ
CryoEM structure of MDA5-dsRNA filament in complex with ADP with 92-degree helical twist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2 of Interferon-induced helicase C domain-containing protein 1 | polymer | 714 | 81967.6 | 1 | UniProt (Q8R5F7) Pfam (PF04851) Pfam (PF18119) Pfam (PF00271) Pfam (PF11648) | Mus musculus (Mouse) | Helicase with 2 CARD domains,Helicard,Interferon induced with helicase C domain protein 1,Melanoma differentiation-associated protein 5,MDA-5,RIG-I-like receptor 2,RLR-2 |
| 2 | B (X) | RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3') | polymer | 15 | 4767.9 | 1 | Pseudomonas virus phi6 | ||
| 3 | C (Y) | RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3') | polymer | 15 | 4807.9 | 1 | Pseudomonas virus phi6 | ||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 91543.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 492.6 | |
| All* | Total formula weight | 92036.1 |
