7BJ6
Inhibitor of MDM2-p53 Interaction
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | E3 ubiquitin-protein ligase Mdm2 | polymer | 98 | 11181.1 | 1 | UniProt (Q00987) Pfam (PF02201) In PDB | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
2 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
4 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
5 | A | (3~{R})-2-[(5-chloranylpyridin-2-yl)methyl]-3-(4-chlorophenyl)-4-fluoranyl-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]-6-(2-oxidanylpropan-2-yl)isoindol-1-one | non-polymer | 545.4 | 1 | Chemie (TVK) | |||
6 | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A: 17 - 109 (UniProt: Q00987)
PDB | External Database | Details |
---|---|---|
Gly 12 | - | expression tag |
Pro 13 | - | expression tag |
Leu 14 | - | expression tag |
Gly 15 | - | expression tag |
Ser 16 | - | expression tag |
Ala 69 | Glu 69 | engineered mutation |
Ala 70 | Lys 70 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 11181.1 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1035.9 | |
All* | Total formula weight | 12217.0 |