7BHX
Crystal structure of MAT2a bound to allosteric inhibitor (compound 31)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | S-adenosylmethionine synthase isoform type-2 | polymer | 397 | 43935.8 | 1 | UniProt (P31153) Pfam (PF00438) Pfam (PF02772) Pfam (PF02773) | Homo sapiens (Human) | AdoMet synthase 2,Methionine adenosyltransferase 2,MAT 2,Methionine adenosyltransferase II,MAT-II |
| 2 | B (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 3 | C (A) | 7-chloranyl-4-(dimethylamino)-1-pyridin-3-yl-quinazolin-2-one | non-polymer | 300.7 | 1 | Chemie (TO5) | |||
| 4 | D (A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
| 5 | E (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | F (A) | water | water | 18.0 | 375 | Chemie (HOH) |
Sequence modifications
A: 1 - 395 (UniProt: P31153)
| PDB | External Database | Details |
|---|---|---|
| Gln -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43935.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 812.8 | |
| All* | Total formula weight | 44748.6 |
