7BHT
Crystal structure of MAT2a with quinazolinone fragment 5 bound in the allosteric site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | S-adenosylmethionine synthase isoform type-2 | polymer | 397 | 43935.8 | 1 | UniProt (P31153) Pfam (PF00438) Pfam (PF02772) Pfam (PF02773) | Homo sapiens (Human) | AdoMet synthase 2,Methionine adenosyltransferase 2,MAT 2,Methionine adenosyltransferase II,MAT-II |
| 2 | B (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) PubChem (679) | |||
| 3 | C (A) | 7-chloranyl-4-(dimethylamino)-1~{H}-quinazolin-2-one | non-polymer | 223.7 | 1 | Chemie (TO8) PubChem (133054303) | |||
| 4 | D (A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (58633578) PubChem (60038769) PubChem (58766358) PubChem (73897310) PubChem (9865603) PubChem (87224684) PubChem (12312798) PubChem (131697735) PubChem (145712080) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) | |||
| 5 | E (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 6 | F (A) | water | water | 18.0 | 399 | Chemie (HOH) |
Sequence modifications
A: 1 - 395 (UniProt: P31153)
| PDB | External Database | Details |
|---|---|---|
| Gln -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43935.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 735.7 | |
| All* | Total formula weight | 44671.5 |
