7BHF

DARPin_D5/Her3 domain 4 complex, orthorhombic crystals

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	DARPin_D5	polymer	138	14908.5	2		synthetic construct
2	B, D (B, D)	Isoform 4 of Receptor tyrosine-protein kinase erbB-3	polymer	150	16140.1	2	UniProt (P21860) Pfam (PF14843)	Homo sapiens (Human)	Proto-oncogene-like protein c-ErbB-3,Tyrosine kinase-type cell surface receptor HER3
3	E, F (A, C)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
4	G, H, I, J (A, B, C, D)	water	water		18.0	690	Chemie (HOH)

Sequence modifications

B, D: 481 - 611 (UniProt: P21860)

PDB	External Database	Details
His 475	-	expression tag
His 476	-	expression tag
His 477	-	expression tag
His 478	-	expression tag
His 479	-	expression tag
His 480	-	expression tag
Gly 612	-	expression tag
Gln 613	-	expression tag
Thr 614	-	expression tag
Leu 615	-	expression tag
Val 616	-	expression tag
Leu 617	-	expression tag
Ile 618	-	expression tag
Gly 619	-	expression tag
Lys 620	-	expression tag
Thr 621	-	expression tag
His 622	-	expression tag
Leu 623	-	expression tag
Thr 624	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	62097.3
Non-Polymers*	Number of molecules	2
	Total formula weight	118.1
All*	Total formula weight	62215.4

*Water molecules are not included.