7BEN
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-253 and COVOX-75 Fabs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F (E, C) | Spike glycoprotein | polymer | 205 | 23150.9 | 2 | UniProt (P0DTC2) Pfam (PF09408) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | S glycoprotein,E2,Peplomer protein |
| 2 | B, G (H, D) | COVOX-253 heavy chain | polymer | 228 | 24371.4 | 2 | Homo sapiens | ||
| 3 | C, H (L, F) | COVOX-253 light chain | polymer | 215 | 23256.6 | 2 | Homo sapiens | ||
| 4 | D, I (A, G) | COVOX-75 heavy chain | polymer | 232 | 24821.8 | 2 | Homo sapiens | ||
| 5 | E, J (B, I) | COVOX-75 light chain | polymer | 214 | 23244.9 | 2 | Homo sapiens | ||
| 6 | K, L (J, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 2 | In PDB GlyTouCan (G21290RB) | |||
| 7 | CA, LA, M, V (F, I, E, B) | IMIDAZOLE | non-polymer | 69.1 | 4 | Chemie (IMD) | |||
| 8 | AA, N, O, U, W (F, E, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 9 | FA, GA, HA, IA, JA... (G, I, H, A, B...) | BROMIDE ION | non-polymer | 79.9 | 14 | Chemie (BR) | |||
| 10 | BA, R (F, L) | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE | non-polymer | 266.3 | 2 | Chemie (PG6) | |||
| 11 | DA, EA (G) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 12 | KA (G) | IODIDE ION | non-polymer | 126.9 | 1 | Chemie (IOD) | |||
| 13 | OA, PA, QA, RA, SA... (E, H, L, A, B...) | water | water | 18.0 | 233 | Chemie (HOH) |
Sequence modifications
E, C: 333 - 528 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Glu 324 | - | expression tag |
| Thr 325 | - | expression tag |
| Gly 326 | - | expression tag |
| His 327 | - | expression tag |
| His 328 | - | expression tag |
| His 329 | - | expression tag |
| His 330 | - | expression tag |
| His 331 | - | expression tag |
| His 332 | - | expression tag |
| Lys 527 | Pro 527 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 237691.3 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1141.1 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 2727.3 | |
| All* | Total formula weight | 241559.6 |
