7BEI

Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-150 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H	COVOX-150 heavy chain	polymer	235	24726.9	1		Homo sapiens
2	L	COVOX-150 light chain	polymer	229	24767.6	1		Homo sapiens
3	E	Spike glycoprotein	polymer	205	23150.9	1	UniProt (P0DTC2) Pfam (PF09408) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	S glycoprotein,E2,Peplomer protein
4	A	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
5	H, L	NITRATE ION	non-polymer		62.0	3	Chemie (NO3)
6	H, L	CHLORIDE ION	non-polymer		35.5	5	Chemie (CL)
7		water	water		18.0	213	Chemie (HOH)

Sequence modifications

E: 333 - 528 (UniProt: P0DTC2)

PDB	External Database	Details
Glu 324	-	expression tag
Thr 325	-	expression tag
Gly 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
Lys 527	Pro 527	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	72645.4
Branched	Number of molecules	1
	Total formula weight	570.5
Non-Polymers*	Number of molecules	8
	Total formula weight	363.3
All*	Total formula weight	73579.2

*Water molecules are not included.