7BEH

Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-316 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (E)	Spike glycoprotein	polymer	205	23150.9	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	S glycoprotein,E2,Peplomer protein
2	B (H)	COVOX-316 heavy chain	polymer	240	25640.9	1		Homo sapiens
3	C (L)	COVOX-316 light chain	polymer	229	24121.7	1		Homo sapiens
4	D, E (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	2	In PDB GlyTouCan (G21290RB)
5	F, G (E, H)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	H, I (H, L)	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		122.1	2	Chemie (TRS)
7	J, K, L (E, H, L)	water	water		18.0	100	Chemie (HOH)

Sequence modifications

E: 333 - 528 (UniProt: P0DTC2)

PDB	External Database	Details
Glu 324	-	expression tag
Thr 325	-	expression tag
Gly 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
Lys 527	Pro 527	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	72913.5
Branched	Number of molecules	2
	Total formula weight	1141.1
Non-Polymers*	Number of molecules	4
	Total formula weight	428.5
All*	Total formula weight	74483.1

*Water molecules are not included.