7BB7
AVP-V2R-Galphas-beta1-gamma2-Nb35(T state)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vasopressin V2 receptor | polymer | 440 | 47886.2 | 1 | UniProt (P30518) Pfam (PF00001) | Homo sapiens (Human) | V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor |
| 2 | B (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 371 | 40507.1 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C (E) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45725.5 | 1 | UniProt (P63092) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
| 4 | D (F) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 5 | E (G) | Nanobody 35 | polymer | 138 | 15140.7 | 1 | Lama glama | ||
| 6 | F (H) | Vasopressin | polymer | 10 | 1086.2 | 1 | Pfam (PF00220) UniProt (by SIFTS) (P01185) | Homo sapiens |
Sequence modifications
A: -5 - 371 (UniProt: P30518)
C: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met -38 | - | initiating methionine |
| Lys -37 | - | expression tag |
| Thr -36 | - | expression tag |
| Ile -35 | - | expression tag |
| Ile -34 | - | expression tag |
| Ala -33 | - | expression tag |
| Leu -32 | - | expression tag |
| Ser -31 | - | expression tag |
| Tyr -30 | - | expression tag |
| Ile -29 | - | expression tag |
| Phe -28 | - | expression tag |
| Cys -27 | - | expression tag |
| Leu -26 | - | expression tag |
| Val -25 | - | expression tag |
| Phe -24 | - | expression tag |
| Ala -23 | - | expression tag |
| Asp -22 | - | expression tag |
| Tyr -21 | - | expression tag |
| Lys -20 | - | expression tag |
| Asp -19 | - | expression tag |
| Asp -18 | - | expression tag |
| Asp -17 | - | expression tag |
| Asp -16 | - | expression tag |
| Ala -15 | - | expression tag |
| Glu -14 | - | expression tag |
| Asn -13 | - | expression tag |
| Leu -12 | - | expression tag |
| Tyr -11 | - | expression tag |
| Phe -10 | - | expression tag |
| Gln -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Ser -6 | - | expression tag |
| Gln 14 | Asn 22 | conflict |
| Leu 23 | - | insertion |
| Glu 24 | - | insertion |
| Val 25 | - | insertion |
| Leu 26 | - | insertion |
| Phe 27 | - | insertion |
| Gln 28 | - | insertion |
| Gly 29 | - | insertion |
| Pro 30 | - | insertion |
| Leu 346 | Arg 346 | conflict |
| Glu 347 | Thr 347 | conflict |
| Val 348 | Pro 348 | conflict |
| Leu 349 | Pro 349 | conflict |
| Phe 350 | Ser 350 | conflict |
| Gln 351 | Leu 351 | conflict |
| Ala 358 | Cys 358 | conflict |
| Leu 372 | - | expression tag |
| Glu 373 | - | expression tag |
| Trp 374 | - | expression tag |
| Ser 375 | - | expression tag |
| His 376 | - | expression tag |
| Pro 377 | - | expression tag |
| Gln 378 | - | expression tag |
| Phe 379 | - | expression tag |
| Glu 380 | - | expression tag |
| Lys 381 | - | expression tag |
| Gly 382 | - | expression tag |
| Gly 383 | - | expression tag |
| Gly 384 | - | expression tag |
| Ser 385 | - | expression tag |
| Gly 386 | - | expression tag |
| Gly 387 | - | expression tag |
| Gly 388 | - | expression tag |
| Ser 389 | - | expression tag |
| Gly 390 | - | expression tag |
| Gly 391 | - | expression tag |
| Gly 392 | - | expression tag |
| Ser 393 | - | expression tag |
| Trp 394 | - | expression tag |
| Ser 395 | - | expression tag |
| His 396 | - | expression tag |
| Pro 397 | - | expression tag |
| Gln 398 | - | expression tag |
| Phe 399 | - | expression tag |
| Glu 400 | - | expression tag |
| Lys 401 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -30 | - | initiating methionine |
| Trp -29 | - | expression tag |
| Ser -28 | - | expression tag |
| His -27 | - | expression tag |
| Pro -26 | - | expression tag |
| Gln -25 | - | expression tag |
| Phe -24 | - | expression tag |
| Glu -23 | - | expression tag |
| Lys -22 | - | expression tag |
| Gly -21 | - | expression tag |
| Gly -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Ser -18 | - | expression tag |
| Gly -17 | - | expression tag |
| Gly -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Gly -14 | - | expression tag |
| Gly -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Trp -10 | - | expression tag |
| Ser -9 | - | expression tag |
| His -8 | - | expression tag |
| Pro -7 | - | expression tag |
| Gln -6 | - | expression tag |
| Phe -5 | - | expression tag |
| Glu -4 | - | expression tag |
| Lys -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 158206.9 | |
| All* | Total formula weight | 158206.9 |
