7B9Z
Structure of the FKBP51FK1 domain in complex with the macrocyclic SAFit analogue 35-(E)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peptidyl-prolyl cis-trans isomerase FKBP5 | polymer | 130 | 14273.4 | 1 | UniProt (Q13451) Pfam (PF00254) | Homo sapiens (Human) | PPIase FKBP5,51 kDa FK506-binding protein,FKBP-51,54 kDa progesterone receptor-associated immunophilin,Androgen-regulated protein 6,FF1 antigen,FK506-binding protein 5,FKBP-5,FKBP54,p54,HSP90-binding immunophilin,Rotamase |
| 2 | B (A) | 2-cyclohexyl-12-[2-(3,4-dimethoxyphenyl)ethyl]-25,26-dimethoxy-11,18,23-trioxa-4-azatetracyclo[22.3.1.113,17.04,9]nonacosa-1(27),13(29),14,16,20,24(28),25-heptaene-3,10-dione | non-polymer | 727.9 | 1 | Chemie (T58) | |||
| 3 | C, D, E (A) | isothiocyanate | non-polymer | 59.1 | 3 | Chemie (IS8) | |||
| 4 | F (A) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A: 16 - 140 (UniProt: Q13451)
| PDB | External Database | Details |
|---|---|---|
| His 11 | - | expression tag |
| Met 12 | - | expression tag |
| Gly 13 | - | expression tag |
| Ala 14 | - | expression tag |
| Pro 15 | - | expression tag |
| Thr 19 | Ala 19 | engineered mutation |
| Ala 103 | Cys 103 | engineered mutation |
| Ile 107 | Cys 107 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 14273.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 905.2 | |
| All* | Total formula weight | 15178.5 |
