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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7B9V

Yeast C complex spliceosome at 2.8 Angstrom resolution with Prp18/Slu7 bound

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(2)		U2 snRNApolymer1175376267.41Saccharomyces cerevisiae
2B
(5)		U5 snRNApolymer21468643.31Saccharomyces cerevisiae
3C
(6)		U6 snRNApolymer11235883.21Saccharomyces cerevisiae
4D
(A)		Pre-mRNA-splicing factor 8polymer2413279867.51UniProt (P33334)
Pfam (PF08082)
Pfam (PF08083)
Pfam (PF10598)
Pfam (PF10597)
Pfam (PF10596)
Pfam (PF12134)
Pfam (PF08084)		Saccharomyces cerevisiae (Baker's yeast)Prp8
5E
(B)		Pre-mRNA-splicing helicase BRR2polymer2163246470.31UniProt (P32639)
Pfam (PF00270)
Pfam (PF00271)
Pfam (PF02889)
Pfam (PF21188)
Pfam (PF18149)		Saccharomyces cerevisiae (Baker's yeast)Protein Snu246, yeast Brr2
6F
(C)		Pre-mRNA-splicing factor SNU114polymer1008114174.01UniProt (A0A6A5PW35)Saccharomyces cerevisiae (Baker's yeast)SNU114 isoform 1
7G
(D)		Splicing factor YJU2polymer29133360.51UniProt (A0A6L1B9A1)Saccharomyces cerevisiae (Baker's yeast)
8H
(E)		5' exon of UBC4 mRNApolymer4715041.91Saccharomyces cerevisiae
9I
(F)		Pre-mRNA-splicing factor CWC25polymer17920010.11UniProt (A0A6A5Q526)Saccharomyces cerevisiae (Baker's yeast)
10J
(G)		Pre-mRNA-splicing factor ISY1polymer23527625.51UniProt (A0A6V8S636)Saccharomyces cerevisiae (Baker's yeast)
11K
(H)		CWC22 isoform 1polymer57767386.11UniProt (A0A6A5Q1E9)Saccharomyces cerevisiae (Baker's yeast)
12L
(I)		Branched intron and 3' exon of UBC4 pre-mRNApolymer9530200.71Saccharomyces cerevisiae
13M
(J)		BJ4_G0054360.mRNA.1.CDS.1polymer45150771.31UniProt (A0A6A5Q605)Saccharomyces cerevisiae (Baker's yeast)PRP46 isoform 1
14N
(K)		Pre-mRNA-processing protein 45polymer37942548.71UniProt (A0A6A5PTY9)Saccharomyces cerevisiae (Baker's yeast)
15O
(L)		BUD31 isoform 1polymer15718484.51UniProt (A0A6A5Q3N1)Saccharomyces cerevisiae (Baker's yeast)EM14S01-3B_G0005920.mRNA.1.CDS.1,HLJ1_G0006010.mRNA.1.CDS.1,JXXY16.1_G0005970.mRNA.1.CDS.1,Pre-mRNA-splicing factor BUD31,SX2_G0005960.mRNA.1.CDS.1,XXYS1_G0005950.mRNA.1.CDS.1,Y55_G0006020.mRNA.1.CDS.1
16P
(M)		Pre-mRNA-splicing factor CWC2polymer33938486.61UniProt (A0A6A5Q155)Saccharomyces cerevisiae (Baker's yeast)
17Q
(N)		Pre-mRNA-splicing factor SLT11polymer36440988.61UniProt (A0A6A5Q0Z2)Saccharomyces cerevisiae (Baker's yeast)
18R
(O)		Y55_G0042700.mRNA.1.CDS.1polymer59067086.01UniProt (A0A6L0ZW46)Saccharomyces cerevisiae (Baker's yeast)
19S
(P)		Pre-mRNA-splicing factor CWC15polymer17519975.21UniProt (A0A6L0Y8G8)Saccharomyces cerevisiae (Baker's yeast)
20T
(Q)		Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16polymer1071121815.21UniProt (A0A6V8RSY7)Saccharomyces cerevisiae (Baker's yeast)
21U
(R)		Pre-mRNA-splicing factor CWC21polymer13515793.61UniProt (A0A6A5PZG6)Saccharomyces cerevisiae (Baker's yeast)
22V
(S)		CLF1 isoform 1polymer68782555.91UniProt (A0A6A5PT67)Saccharomyces cerevisiae (Baker's yeast)Pre-mRNA-splicing factor CLF1
23W
(T)		SYF1 isoform 1polymer859100344.01UniProt (A0A6A5Q0A4)Saccharomyces cerevisiae (Baker's yeast)
24X
(W)		HLJ1_G0053790.mRNA.1.CDS.1polymer23827232.31UniProt (A0A6A5Q2G3)Saccharomyces cerevisiae (Baker's yeast)LEA1 isoform 1,Y55_G0053650.mRNA.1.CDS.1
25Y
(X)		Unassigned structurepolymer24020443.11Saccharomyces cerevisiae
26Z
(Y)		BJ4_G0027490.mRNA.1.CDS.1polymer11112850.91UniProt (A0A6A5Q318)Saccharomyces cerevisiae (Baker's yeast)HN1_G0027200.mRNA.1.CDS.1,MSL1 isoform 1,SX2_G0029270.mRNA.1.CDS.1,Y55_G0027550.mRNA.1.CDS.1
27AA
(Z)		NTC20 isoform 1polymer14015992.91UniProt (A0A6A5Q1C0)Saccharomyces cerevisiae (Baker's yeast)
28BA
(a)		Pre-mRNA-splicing factor 18polymer25128414.41UniProt (A0A6A5PX22)Saccharomyces cerevisiae (Baker's yeast)
29CA, KA
(b, k)		Small nuclear ribonucleoprotein-associated protein Bpolymer19622427.02UniProt (P40018)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)snRNP-B,Sm protein B,SmB, U5 SmB
30DA
(c)		Pre-mRNA-splicing factor SLU7polymer38244722.91UniProt (A0A6V8RGB0)Saccharomyces cerevisiae (Baker's yeast)
31EA, NA
(d, n)		Small nuclear ribonucleoprotein Sm D3polymer10111240.12UniProt (P43321)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)Sm-D3,snRNP core protein D3, U5 SmD3
32FA, PA
(e, p)		Small nuclear ribonucleoprotein Epolymer9410385.12UniProt (Q12330)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)snRNP-E,Sm protein E,SmE, U5 SmE
33GA, QA
(f, q)		Small nuclear ribonucleoprotein Fpolymer869669.92UniProt (P54999)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)snRNP-F,Sm protein F,SmF
34HA, RA
(g, r)		Small nuclear ribonucleoprotein Gpolymer778490.82UniProt (P40204)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)snRNP-G,Sm protein G,SmG
35IA, LA
(h, l)		Small nuclear ribonucleoprotein Sm D1polymer14616296.82UniProt (Q02260)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)Sm-D1,snRNP core protein D1, U4 SmD1
36JA, MA
(j, m)		Small nuclear ribonucleoprotein Sm D2polymer11012876.12UniProt (Q06217)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)Sm-D2,snRNP core protein D2, SmD2
37OA
(o)		CDC40 isoform 1polymer45552208.71UniProt (A0A6A5PYD5)Saccharomyces cerevisiae (Baker's yeast)
38SA
(s)		SNT309 isoform 1polymer17520741.51UniProt (A0A6A5Q641)Saccharomyces cerevisiae (Baker's yeast)Y55_G0056570.mRNA.1.CDS.1
39TA, UA, VA, WA
(t, u, v, w)		Pre-mRNA-processing factor 19polymer50356629.84UniProt (A0A6A5PQI0)Saccharomyces cerevisiae (Baker's yeast)
40XA
(y)		Pre-mRNA-splicing factor SYF2polymer21524850.71UniProt (A0A6A5PX61)Saccharomyces cerevisiae (Baker's yeast)Pre-mRNA-splicing factor syf2
41AB, BB, CB, FB, YA...
(6, C)		MAGNESIUM IONnon-polymer24.36Chemie (MG)
42DB
(6)		POTASSIUM IONnon-polymer39.11Chemie (K)
43EB
(A)		D-chiro inositol hexakisphosphatenon-polymer660.01Chemie (KGN)
44GB
(C)		GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
45HB, IB, JB, KB, LB...
(D, L, M, N, c)		ZINC IONnon-polymer65.48Chemie (ZN)
Sequence modifications
D: 1 - 289 (UniProt: A0A6L1B9A1)
PDBExternal DatabaseDetails
Unk 218-insertion
Unk 219-insertion
Unk 220-insertion
Unk 221-insertion
Unk 222-insertion
Unk 223-insertion
Unk 224-insertion
Unk 225-insertion
Unk 226-insertion
Unk 227-insertion
Unk 228-insertion
Unk 229-insertion
Unk 230-insertion
Unk 231-insertion
Unk 232-insertion
Unk 233-insertion
Unk 234-insertion
-Asp 237deletion
-Asn 238deletion
-Asn 239deletion
-Asp 240deletion
F: 1 - 179 (UniProt: A0A6A5Q526)
PDBExternal DatabaseDetails
Unk 72Lys 72conflict
Unk 73Lys 73conflict
Unk 74Ser 74conflict
Unk 75Gly 75conflict
Unk 76Leu 76conflict
Unk 77Glu 77conflict
Unk 78Trp 78conflict
Unk 79Met 79conflict
Unk 80Tyr 80conflict
Unk 81Gln 81conflict
G: 1 - 235 (UniProt: A0A6V8S636)
PDBExternal DatabaseDetails
Unk 163Arg 163conflict
Unk 164Asn 164conflict
Unk 165Asp 165conflict
Unk 166Phe 166conflict
Unk 167Tyr 167conflict
Unk 168Tyr 168conflict
Unk 169His 169conflict
Unk 170Gly 170conflict
Unk 171Lys 171conflict
Unk 172Val 172conflict
Unk 173Thr 173conflict
O: 1 - 590 (UniProt: A0A6L0ZW46)
PDBExternal DatabaseDetails
Ala 125Val 125conflict
Unk 304Thr 304conflict
Unk 305Lys 305conflict
Unk 306Gln 306conflict
Unk 307Gly 307conflict
Unk 308Lys 308conflict
Unk 309Val 309conflict
Unk 310Thr 310conflict
Unk 311Tyr 311conflict
Unk 312Lys 312conflict
Unk 313Lys 313conflict
Unk 314Lys 314conflict
Unk 315Leu 315conflict
Unk 316Glu 316conflict
Unk 317Ser 317conflict
Unk 318Lys 318conflict
Unk 319Arg 319conflict
Unk 320Gln 320conflict
Unk 321Lys 321conflict
Unk 322Leu 322conflict
Unk 323Ile 323conflict
Unk 324Glu 324conflict
Unk 325Ala 325conflict
Unk 326Gln 326conflict
Unk 327Ala 327conflict
P: 1 - 175 (UniProt: A0A6L0Y8G8)
PDBExternal DatabaseDetails
Arg 49Lys 49conflict
Met 68Val 68conflict
Val 99Ile 99conflict
c: 1 - 382 (UniProt: A0A6V8RGB0)
PDBExternal DatabaseDetails
Glu 9Lys 9conflict
Asn 154Thr 154conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains50
Total formula weight2570528.1
Non-Polymers*Number of molecules17
Total formula weight1891.4
All*Total formula weight2572419.6
*Water molecules are not included.

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PDB entries from 2024-10-30

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