7B9H
Crystal structure of the PDE4D catalytic domain in complex with GEBR-42a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 343 | 39624.9 | 2 | UniProt (Q08499) Pfam (PF00233) | Homo sapiens (Human) | DPDE3,PDE43 |
| 2 | AA, C (B, A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | BA, CA, D, DA, E... (B, A) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 4 | EA, FA, GA, HA, I... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 28 | Chemie (EDO) | |||
| 5 | PA, Z (B, A) | 3-[(~{E})-1-(3-cyclopentyloxy-4-methoxy-phenyl)ethylideneamino]oxy-1-morpholin-4-yl-propan-1-one | non-polymer | 390.5 | 2 | Chemie (T3K) | |||
| 6 | QA, RA (A, B) | water | water | 18.0 | 686 | Chemie (HOH) |
Sequence modifications
A, B: 78 - 412 (UniProt: Q08499)
| PDB | External Database | Details |
|---|---|---|
| Met 77 | - | initiating methionine |
| Ala 413 | - | expression tag |
| His 414 | - | expression tag |
| His 415 | - | expression tag |
| His 416 | - | expression tag |
| His 417 | - | expression tag |
| His 418 | - | expression tag |
| His 419 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79249.9 | |
| Non-Polymers* | Number of molecules | 40 |
| Total formula weight | 2844.1 | |
| All* | Total formula weight | 82094.0 |
