7B8T

Levofloxacin bound structure of bacterial efflux pump.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB	polymer	613	66099.0	3	UniProt (P31224) Pfam (PF00873)	Escherichia coli (strain K12)	AcrAB-TolC multidrug efflux pump subunit AcrB,Acridine resistance protein B,AcrAB-TolC multidrug efflux pump subunit AcrB,Acridine resistance protein B
2	D, E, F (D, E, F)	DARPin	polymer	169	18317.6	3		synthetic construct
3	G (C)	(3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid	non-polymer		361.4	1	Chemie (LFX)
4	H, I, J (A, B, C)	water	water		18.0	10	Chemie (HOH)

Sequence modifications

A, B, C: 39 - 329 (UniProt: P31224)

PDB	External Database	Details
Ser 38	-	expression tag

A, B, C: 561 - 869 (UniProt: P31224)

PDB	External Database	Details
Gly 552	-	linker
Gly 553	-	linker
Ser 554	-	linker
Gly 555	-	linker
Gly 556	-	linker
Ser 557	-	linker
Gly 558	-	linker
Gly 559	-	linker
Ser 560	-	linker
Ser 870	-	expression tag
Ala 871	-	expression tag
Leu 872	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	253249.8
Non-Polymers*	Number of molecules	1
	Total formula weight	361.4
All*	Total formula weight	253611.2

*Water molecules are not included.