7B7N

Human herpesvirus-8 gH/gL in complex with EphA2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (E)	Ephrin type-A receptor 2	polymer	215	24043.9	1	UniProt (P29317) Pfam (PF01404)	Homo sapiens (Human)	Epithelial cell kinase,Tyrosine-protein kinase receptor ECK
2	B (H)	Envelope glycoprotein H	polymer	681	76019.0	1	UniProt (Q98142) Pfam (PF02489) Pfam (PF17488)	Human herpesvirus 8 (HHV-8)	gH
3	C (L)	Envelope glycoprotein L	polymer	184	19651.0	1	UniProt (Q76RG7) Pfam (PF11108) UniProt (by SIFTS) (F5HDB7)	Human herpesvirus 8 (HHV-8)	gL
4	D, E (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	F, G, H, R (E, L)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
6	I, J, L, M, N... (E, H, L)	SODIUM ION	non-polymer		23.0	10	Chemie (NA)
7	K, Q (H, L)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
8	V, W, X (E, H, L)	water	water		18.0	54	Chemie (HOH)

Sequence modifications

E: 23 - 202 (UniProt: P29317)

PDB	External Database	Details
Asp 203	-	expression tag
Asp 204	-	expression tag
Asp 205	-	expression tag
Asp 206	-	expression tag
Lys 207	-	expression tag
Ala 208	-	expression tag
Gly 209	-	expression tag
Trp 210	-	expression tag
Ser 211	-	expression tag
His 212	-	expression tag
Pro 213	-	expression tag
Gln 214	-	expression tag
Phe 215	-	expression tag
Glu 216	-	expression tag
Lys 217	-	expression tag
Gly 218	-	expression tag
Gly 219	-	expression tag
Gly 220	-	expression tag
Ser 221	-	expression tag
Gly 222	-	expression tag
Gly 223	-	expression tag
Gly 224	-	expression tag
Ser 225	-	expression tag
Gly 226	-	expression tag
Gly 227	-	expression tag
Gly 228	-	expression tag
Ser 229	-	expression tag
Trp 230	-	expression tag
Ser 231	-	expression tag
His 232	-	expression tag
Pro 233	-	expression tag
Gln 234	-	expression tag
Phe 235	-	expression tag
Glu 236	-	expression tag
Lys 237	-	expression tag

H: 26 - 704 (UniProt: Q98142)

PDB	External Database	Details
Arg 24	-	cloning artifact
Ser 25	-	cloning artifact

L: 21 - 167 (UniProt: Q76RG7)

PDB	External Database	Details
Arg 19	-	cloning artifact
Ser 20	-	cloning artifact
Ser 58	Cys 58	engineered mutation
Asp 168	-	expression tag
Asp 169	-	expression tag
Asp 170	-	expression tag
Asp 171	-	expression tag
Lys 172	-	expression tag
Ala 173	-	expression tag
Gly 174	-	expression tag
Trp 175	-	expression tag
Ser 176	-	expression tag
His 177	-	expression tag
Pro 178	-	expression tag
Gln 179	-	expression tag
Phe 180	-	expression tag
Glu 181	-	expression tag
Lys 182	-	expression tag
Gly 183	-	expression tag
Gly 184	-	expression tag
Gly 185	-	expression tag
Ser 186	-	expression tag
Gly 187	-	expression tag
Gly 188	-	expression tag
Gly 189	-	expression tag
Ser 190	-	expression tag
Gly 191	-	expression tag
Gly 192	-	expression tag
Gly 193	-	expression tag
Ser 194	-	expression tag
Trp 195	-	expression tag
Ser 196	-	expression tag
His 197	-	expression tag
Pro 198	-	expression tag
Gln 199	-	expression tag
Phe 200	-	expression tag
Glu 201	-	expression tag
Lys 202	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	119713.9
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	16
	Total formula weight	814.1
All*	Total formula weight	121376.8

*Water molecules are not included.