7B4H
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (III)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cellular tumor antigen p53 | polymer | 200 | 22505.6 | 1 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (Human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | B (B) | DNA target | polymer | 12 | 3664.4 | 1 | synthetic construct | ||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | F, G (A) | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one | non-polymer | 139.2 | 2 | Chemie (QN8) | |||
| 7 | H (A) | (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one | non-polymer | 139.2 | 1 | Chemie (QNN) | |||
| 8 | I, J, K, L (A, B) | FORMIC ACID | non-polymer | 46.0 | 4 | Chemie (FMT) | |||
| 9 | M, N (A, B) | water | water | 18.0 | 276 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26170.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 788.2 | |
| All* | Total formula weight | 26958.2 |
