7B4A
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA: R273H-DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cellular tumor antigen p53 | polymer | 200 | 22486.5 | 2 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (Human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | C (C) | DNA target | polymer | 20 | 6136.9 | 1 | synthetic construct | ||
| 3 | D, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, G (A, B) | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
| 5 | H, I, J (A, B, C) | water | water | 18.0 | 510 | Chemie (HOH) |
Sequence modifications
A, B: 94 - 293 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| His 273 | Arg 273 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 51110.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 222.9 | |
| All* | Total formula weight | 51332.9 |
