7B46
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (P1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cellular tumor antigen p53 | polymer | 200 | 22505.6 | 4 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (Human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | E, F, G, H (E, F, G, H) | DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3') | polymer | 12 | 3664.4 | 4 | synthetic construct | ||
| 3 | I, M, P, S (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | J, K, L, N, Q... (A, B, C, D) | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one | non-polymer | 139.2 | 7 | Chemie (QN8) | |||
| 5 | O (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) PubChem (175) | |||
| 6 | T (D) | (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one | non-polymer | 139.2 | 1 | Chemie (QNN) PubChem (93514107) PubChem (93514108) PubChem (12381698) | |||
| 7 | AA, BA, CA, V, W... (F, G, H, A, B...) | water | water | 18.0 | 295 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 104679.8 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1434.2 | |
| All* | Total formula weight | 106114.1 |
