7B43
Crystal structure of c-MET bound by compound 9
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hepatocyte growth factor receptor | polymer | 299 | 33786.2 | 2 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (Human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | C, D (A, B) | 3-[(4-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine | non-polymer | 375.4 | 2 | Chemie (SW5) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A, B: 1049 - 1346 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Gly 1048 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67572.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 750.9 | |
| All* | Total formula weight | 68323.3 |
