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7B3M

MEK1 in complex with compound 6

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BDual specificity mitogen-activated protein kinase kinase 1,Dual specificity mitogen-activated protein kinase kinase 1polymer32636558.02UniProt (Q02750)
Pfam (PF00069)
In PDB
Homo sapiens (Human)MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1,MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1
2A, BMAGNESIUM IONnon-polymer24.32Chemie (MG)
3A, BPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERnon-polymer506.22Chemie (ANP)
4A, B1~{H}-indol-2-yl(pyridin-3-yl)methanonenon-polymer222.22Chemie (SU5)
5ASULFATE IONnon-polymer96.11Chemie (SO4)
6waterwater18.0153Chemie (HOH)
Sequence modifications
A, B: 37 - 263 (UniProt: Q02750)
PDBExternal DatabaseDetails
Met 20-initiating methionine
Ala 21-expression tag
His 22-expression tag
His 23-expression tag
His 24-expression tag
His 25-expression tag
His 26-expression tag
His 27-expression tag
Ala 28-expression tag
Ala 29-expression tag
Ala 30-expression tag
Glu 31-expression tag
Asn 32-expression tag
Leu 33-expression tag
Tyr 34-expression tag
Phe 35-expression tag
Gln 36-expression tag
A, B: 308 - 383 (UniProt: Q02750)
PDBExternal DatabaseDetails
Gly 264-linker
Ser 303-linker
Gly 304-linker
Ser 305-linker
Gly 306-linker
Ser 307-linker
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight73116.0
Non-Polymers*Number of molecules7
Total formula weight1601.5
All*Total formula weight74717.6
*Water molecules are not included.

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PDB entries from 2024-06-12

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