7B1Q
Crystal Structure of Human BACE-1 in Complex with Compound NB-360 (compound 54)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Beta-secretase 1 | polymer | 402 | 44777.3 | 1 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (Human) | Aspartyl protease 2,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2 |
2 | A | ~{N}-[3-[(3~{R},6~{R})-5-azanyl-3,6-dimethyl-6-(trifluoromethyl)-2~{H}-1,4-oxazin-3-yl]-4-fluoranyl-phenyl]-5-cyano-3-methyl-pyridine-2-carboxamide | non-polymer | 449.4 | 1 | Chemie (SLK) | |||
3 | water | water | 18.0 | 245 | Chemie (HOH) |
Sequence modifications
A: 35 - 386 (UniProt: P56817)
PDB | External Database | Details |
---|---|---|
Gly | - | expression tag |
Pro | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 44777.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 449.4 | |
All* | Total formula weight | 45226.7 |