7B1P
Crystal Structure of Human BACE-1 in Complex with Compound 38a (NB-854)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-secretase 1 | polymer | 402 | 44777.3 | 1 | UniProt (P56817) Pfam (PF00026) | Homo sapiens (Human) | Aspartyl protease 2,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2 |
| 2 | B (A) | ~{N}-[3-[(3~{R},6~{R})-5-azanyl-3,6-dimethyl-6-(trifluoromethyl)-2~{H}-1,4-oxazin-3-yl]phenyl]-5-bromanyl-pyridine-2-carboxamide | non-polymer | 471.3 | 1 | Chemie (SL8) | |||
| 3 | C (A) | water | water | 18.0 | 336 | Chemie (HOH) |
Sequence modifications
A: 35 - 386 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Gly | - | expression tag |
| Pro | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44777.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 471.3 | |
| All* | Total formula weight | 45248.6 |
