7B0T

Crystal structure of MLLT1 YEATS domain T3 mutant in complex with benzimidazole-amide based compound 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Protein ENL	polymer	152	18045.8	1	UniProt (Q03111) Pfam (PF03366) In PDB	Homo sapiens (Human)	YEATS domain-containing protein 1
2	A	3-iodanyl-4-methyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide	non-polymer		474.3	1	Chemie (GKT)
3	A	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
4		water	water		18.0	13	Chemie (HOH)

Sequence modifications

A: 1 - 146 (UniProt: Q03111)

PDB	External Database	Details
Lys 111	Asn 111	engineered mutation
-	Pro 112	deletion
-	Pro 113	deletion
His 147	-	expression tag
His 148	-	expression tag
His 149	-	expression tag
His 150	-	expression tag
His 151	-	expression tag
His 152	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	18045.8
Non-Polymers*	Number of molecules	6
	Total formula weight	784.7
All*	Total formula weight	18830.5

*Water molecules are not included.