7AZ2
14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1014
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 14-3-3 protein sigma | polymer | 252 | 28169.5 | 1 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (Human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B (P) | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | polymer | 17 | 2195.4 | 1 | UniProt (Q13526) | Homo sapiens | Peptidyl-prolyl cis-trans isomerase Pin1,PPIase Pin1,Rotamase Pin1 |
| 3 | C (A) | 1-[4-methyl-2-(trifluoromethyl)phenyl]-2-phenyl-imidazole | non-polymer | 302.3 | 1 | Chemie (SFW) | |||
| 4 | D, E (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 5 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | G, H (A, P) | water | water | 18.0 | 352 | Chemie (HOH) |
Sequence modifications
A: 1 - 248 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30364.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 417.9 | |
| All* | Total formula weight | 30782.8 |
