7AYQ

Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, B114

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Dipeptidyl peptidase 8	polymer	898	103483.4	2	UniProt (Q6V1X1) Pfam (PF19520) Pfam (PF00930) Pfam (PF00326)	Homo sapiens (Human)	DP8,Dipeptidyl peptidase IV-related protein 1,DPRP-1,Dipeptidyl peptidase VIII,DPP VIII,Prolyl dipeptidase DPP8
2	C, G (A, B)	trimethylamine oxide	non-polymer		75.1	2	Chemie (TMO)
3	D, H (A, B)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
4	E, I (A, B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	F, J (A, B)	~{N}-[3-[4-[(4-bromophenyl)methyl]piperazin-1-yl]carbonylphenyl]-2-ethyl-2-methanoyl-butanamide	non-polymer		500.4	2	Chemie (S9Z)
6	K, L (A, B)	water	water		18.0	165	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	206966.7
Non-Polymers*	Number of molecules	8
	Total formula weight	1525.2
All*	Total formula weight	208491.9

*Water molecules are not included.