7AXW
Crystal structure of the cAMP-dependent protein kinase A cocrystallized with 1-aminoisoquinoline and PKI (5-24)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 353 | 41113.8 | 1 | UniProt (P25321) Pfam (PF00069) In PDB | Cricetulus griseus (Chinese hamster) | PKA C-alpha |
| 2 | B | cAMP-dependent protein kinase inhibitor alpha | polymer | 20 | 2226.4 | 1 | UniProt (P63248) In PDB | Mus musculus | PKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform |
| 3 | A | ISOQUINOLIN-1-AMINE | non-polymer | 144.2 | 1 | Chemie (1SQ) | |||
| 4 | water | water | 18.0 | 295 | Chemie (HOH) |
Sequence modifications
A: 0 - 350 (UniProt: P25321)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| His -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43340.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 144.2 | |
| All* | Total formula weight | 43484.4 |
