7AW3
MerTK kinase domain with type 1 inhibitor from a DNA-encoded library
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase Mer | polymer | 298 | 34381.8 | 1 | UniProt (Q12866) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-Mer,Receptor tyrosine kinase MerTK |
2 | A | 2-(1-((5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxamido)methyl)-2-azabicyclo[2.1.1]hexan-2-yl)-N-methyl-4-(trifluoromethyl)thiazole-5-carboxamide | non-polymer | 498.9 | 1 | Chemie (S4Z) | |||
3 | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A: 571 - 864 (UniProt: Q12866)
PDB | External Database | Details |
---|---|---|
Gly 567 | - | expression tag |
Ser 568 | - | expression tag |
His 569 | - | expression tag |
Met 570 | - | expression tag |
Arg 591 | Lys 591 | engineered mutation |
Arg 693 | Lys 693 | engineered mutation |
Arg 702 | Lys 702 | engineered mutation |
Arg 856 | Lys 856 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34381.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 498.9 | |
All* | Total formula weight | 34880.7 |