7AVZ
MerTK kinase domain in complex with a bisaminopyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase Mer | polymer | 298 | 34381.8 | 1 | UniProt (Q12866) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-Mer,Receptor tyrosine kinase MerTK |
| 2 | B (A) | (R)-N2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-5-(3-methylpiperazin-1-yl)-N4-(tetrahydro-2H-pyran-4-yl)pyrimidine-2,4-diamine | non-polymer | 474.5 | 1 | Chemie (S4N) | |||
| 3 | C (A) | water | water | 18.0 | 67 | Chemie (HOH) |
Sequence modifications
A: 571 - 864 (UniProt: Q12866)
| PDB | External Database | Details |
|---|---|---|
| Gly 567 | - | expression tag |
| Ser 568 | - | expression tag |
| His 569 | - | expression tag |
| Met 570 | - | expression tag |
| Arg 591 | Lys 591 | engineered mutation |
| Arg 693 | Lys 693 | engineered mutation |
| Arg 702 | Lys 702 | engineered mutation |
| Arg 856 | Lys 856 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34381.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 474.5 | |
| All* | Total formula weight | 34856.3 |
