7AVY
MerTK kinase domain in complex with quinazoline-based inhbitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase Mer | polymer | 296 | 34000.4 | 1 | UniProt (Q12866) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-Mer,Receptor tyrosine kinase MerTK |
| 2 | B (A) | N-(2-(2-cyclopropylethoxy)pyrimidin-5-yl)-7-methoxy-6-(piperidin-4-ylmethoxy)quinazolin-4-amine | non-polymer | 450.5 | 1 | Chemie (S4E) | |||
| 3 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F (A) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A: 570 - 864 (UniProt: Q12866)
| PDB | External Database | Details |
|---|---|---|
| Gly 569 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34000.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 738.7 | |
| All* | Total formula weight | 34739.1 |
