7AVU
Crystal structure of SOS1 in complex with compound 8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Son of sevenless homolog 1 | polymer | 487 | 57103.3 | 2 | UniProt (Q07889) Pfam (PF00618) Pfam (PF00617) In PDB | Homo sapiens (Human) | SOS-1 |
| 2 | A | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 3 | A, B | ~{N}-[(1~{R})-1-[3-azanyl-5-(trifluoromethyl)phenyl]ethyl]-6,7-dimethoxy-2-methyl-quinazolin-4-amine | non-polymer | 406.4 | 2 | Chemie (S3Z) | |||
| 4 | water | water | 18.0 | 524 | Chemie (HOH) |
Sequence modifications
A, B: 564 - 1049 (UniProt: Q07889)
| PDB | External Database | Details |
|---|---|---|
| Gly 563 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 114206.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 881.9 | |
| All* | Total formula weight | 115088.5 |
