7AS3
Influenza A PB2 (H357N mutation) in complex with VX-787
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Polymerase basic protein 2 | polymer | 171 | 19327.4 | 1 | UniProt (C3W5X5) Pfam (PF00604) In PDB | Influenza A virus (A/California/07/2009(H1N1)) | RNA-directed RNA polymerase subunit P3 |
| 2 | A | (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid | non-polymer | 399.4 | 2 | Chemie (21G) | |||
| 3 | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
A: 320 - 483 (UniProt: C3W5X5)
| PDB | External Database | Details |
|---|---|---|
| Asn 357 | His 357 | engineered mutation |
| Gly 484 | - | expression tag |
| Leu 485 | - | expression tag |
| Glu 486 | - | expression tag |
| Val 487 | - | expression tag |
| Leu 488 | - | expression tag |
| Phe 489 | - | expression tag |
| Gln 490 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19327.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 798.8 | |
| All* | Total formula weight | 20126.2 |
