7AS1
Influenza A PB2 (F404Y mutation) in complex with VX-787
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polymerase basic protein 2 | polymer | 164 | 18580.5 | 1 | UniProt (C3W5X5) Pfam (PF00604) | Influenza A virus (A/California/07/2009(H1N1)) | RNA-directed RNA polymerase subunit P3 |
| 2 | B (A) | (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid | non-polymer | 399.4 | 1 | Chemie (21G) | |||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D (A) | water | water | 18.0 | 236 | Chemie (HOH) |
Sequence modifications
A: 320 - 483 (UniProt: C3W5X5)
| PDB | External Database | Details |
|---|---|---|
| Tyr 404 | Phe 404 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18580.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 434.8 | |
| All* | Total formula weight | 19015.4 |
