7APJ
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RAC-alpha serine/threonine-protein kinase,Non-specific serine/threonine protein kinase,RAC-alpha serine/threonine-protein kinase | polymer | 440 | 51408.7 | 1 | UniProt (P31749) UniProt (M4MD44) Pfam (PF00169) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (Human) | Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha,Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha |
| 2 | B (B) | NB41 | polymer | 126 | 13883.6 | 1 | Lama glama | ||
| 3 | C, D (A, B) | water | water | 18.0 | 163 | Chemie (HOH) |
Sequence modifications
A: 1 - 119 (UniProt: P31749)
A: 120 - 126 (UniProt: M4MD44)
A: 127 - 438 (UniProt: P31749)
| PDB | External Database | Details |
|---|---|---|
| Ala -1 | - | expression tag |
| Arg 0 | - | expression tag |
| Asn 2 | Ser 2 | engineered mutation |
A: 127 - 438 (UniProt: P31749)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65292.3 | |
| All* | Total formula weight | 65292.3 |
