7APJ

Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	RAC-alpha serine/threonine-protein kinase,Non-specific serine/threonine protein kinase,RAC-alpha serine/threonine-protein kinase	polymer	440	51408.7	1	UniProt (P31749) UniProt (M4MD44) Pfam (PF00169) Pfam (PF00069) Pfam (PF00433) In PDB	Homo sapiens (Human)	Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha,Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha
2	B	NB41	polymer	126	13883.6	1		Lama glama
3		water	water		18.0	163	Chemie (HOH)

Sequence modifications

A: 1 - 119 (UniProt: P31749)

PDB	External Database	Details
Ala -1	-	expression tag
Arg 0	-	expression tag
Asn 2	Ser 2	engineered mutation

A: 120 - 126 (UniProt: M4MD44)
A: 127 - 438 (UniProt: P31749)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65292.3
All*	Total formula weight	65292.3

*Water molecules are not included.