7AKH
Structure of DYRK2 in complex with compound 58
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | polymer | 429 | 49600.9 | 1 | UniProt (Q92630) Pfam (PF00069) In PDB | Homo sapiens (Human) | |
2 | A | 4-[3-[(2~{S})-2-(6-bromanylpyridin-2-yl)oxypropyl]-2-methyl-imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine | non-polymer | 454.3 | 1 | Chemie (RK8) | |||
3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
4 | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A: 146 - 552 (UniProt: Q92630)
PDB | External Database | Details |
---|---|---|
Met 124 | - | initiating methionine |
His 125 | - | expression tag |
His 126 | - | expression tag |
His 127 | - | expression tag |
His 128 | - | expression tag |
His 129 | - | expression tag |
His 130 | - | expression tag |
Ser 131 | - | expression tag |
Ser 132 | - | expression tag |
Gly 133 | - | expression tag |
Val 134 | - | expression tag |
Asp 135 | - | expression tag |
Leu 136 | - | expression tag |
Gly 137 | - | expression tag |
Thr 138 | - | expression tag |
Glu 139 | - | expression tag |
Asn 140 | - | expression tag |
Leu 141 | - | expression tag |
Tyr 142 | - | expression tag |
Phe 143 | - | expression tag |
Gln 144 | - | expression tag |
Ser 145 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 49600.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 489.8 | |
All* | Total formula weight | 50090.7 |